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This dual-hormone approach is why tirzepatide is often described as a dual agonist. It works on two different pathways to manage blood sugar and appetite

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Overall, across the entire 88 weeks, participants on Tirzepatide lost about 25% of their starting weight, while those on placebo lost about 10%

Despite the fact that plasticity of excitatory synaptic transmission to interneurons has been studied in much less detail than in pyramids and other excitatory cells, an abundance of forms and mechanisms of plasticity have been observed in interneurons