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Cagrilintide can increase the sensitivity of leptin receptors and potentiate leptin-induced activation of signal transducer and activator of transcription 3 (STAT3), a transcription factor that mediates leptins effects on gene expression (Lutz et al., 2015, Front Endocrinol (Lausanne))
What is most disturbing is the rise in children under the age of 5 who are now overweight or living with obesity
Indeed, the Obesity Medicine Association (OMA) lists four pillars of obesity treatment: nutrition, physical activity, behavior and medication, with nutrition and physical activity being the first lines of defense
For patients seeking maximum weight loss efficiency, tirzepatide may reduce the total treatment duration needed, offsetting higher monthly costs with faster results
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