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It is worth mentioning that SGLT-2 inhibitor use is restricted in patients with renal failure, in which case GLP-1 receptor agonists are considered (down to an eGFR of 15 ml/ml) [68]

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Metabolic Health & Insulin Sensitivity Modulation of NNMT activity has been associated with improved glucose handling and insulin sensitivity, suggesting potential benefits in metabolic syndrome and related conditions

Phase 2/II: Phase 2 awards are often a Follow On application awarded after startups have successfully been awarded a Phase 1 proposal, have achieved the established technical merit of their R&D, and apply and compete successfully for the prototyping and field-testing Phase 2 of their project