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The dual-targeting significantly increased the permeability of 3-PLG-dopa-A-GSH (P app : 14.61 10 6 cm/s) compared to the non-targeted 3-PLG-dopa (P app : 12.39 10 6 cm/s) group (Fig

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Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-) have been positively correlated with blood pressure (40, 41), and the inhibition of DPP-4 has been shown to down-regulate the expression of IL-6 and TNF- (36, 42, 43)