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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

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290 With aging, mitochondrial dysfunction and genomic instability can lead to the buildup of oxidative stress and DNA damage, which can disrupt energy production and genomic maintenance in motor neurons, processes implicated in ALS pathogenesis

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