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More recent systematic reviews and meta-analyses published between 2020 and 2022 have broadly confirmed this picture, reporting small, short-term reductions in body weight and body mass index, particularly in older adults and individuals with obesity or metabolic conditions, but with effect sizes that remain clinically modest

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About half of Americans approve of using weight-loss drugs to treat obesity, AP-NORC poll finds. AP News

Gut microbiota disruption has the potential to provoke a number of processes, including neuroinflammation, BBB dysfunction, dysregulation in immunity, and new patterns in neurotransmitter metabolism