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Cell Death Dis 7(10):e2432 Ma N, Zhang J, Reiter RJ, Ma X (2020) Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation

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Secondary outcomes included BMI % difference and HbA1c difference from baseline

For example, in the case of amylin biology, significant translational gaps between rodent and human systems persist, the optimal receptor selectivity profile for clinical use remains unclear, and molecules continue to advance in clinical development despite these uncertainties (Hollander et al., 2020)