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However, because they initially absorb through oral membranes, bypassing the stomach to go straight to the bloodstream, they shouldnt need as high of a dose.6 Research indicates a certain amount of difficulty absorbing peptides through regular digestion, so sublingual absorption could prove superior.7 The only problem is that sublingual delivery mechanisms for semaglutide haven't been tested to establish an effective dose outside of the compounding pharmacy industrys internal publications, which are more marketing materials than clinical research

Diaz-Jimenez, D., Petrillo, M

Some people also have a genetic predisposition for the condition