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Shami et al., 2003] were selectively activated by GST M1 and GST A1, respectively, and produced abundant NO in the tumor and contributed to chemotherapy by GSH consumption, DNA synthesis inhibition and inhibition of enzymes responsible for cellular damage repair ( Figure 2E )
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Serotonin is a neurotransmitter that plays a crucial role in regulating mood and cognitive functions
Furthermore, it was demonstrated that GLP-1 receptor plays a regulatory role in the hippocampal function and GLP-1 receptor agonists enhanced GABAA signaling through pre-and postsynaptic mechanisms in rats [57], while exendin-4 therapy normalized cognitive dysfunction and improved impaired hippocampal synaptic plasticity in a mice model of diet-induced obesity [58]
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