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After bolus intravenous administration of Lcarnitine in doses ranging from 20 to 100 mg/kg, the volume of distribution is 0.20.3 L/kg, and the fraction excreted unchanged in urine is 0.730.95, suggesting that renal clearance of Lcarnitine is dose dependent due to saturable renal reabsorption at supraphysiological concentrations

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