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Downregulated expression of occludin and zonula occludens-1 is related to increased matrix metalloproteinases levels in diabetes in both rats and humans [37,38], and inhibition of matrix metalloproteinase-9 prevents increased leakage in streptozotocin-induced diabetic mice [39]

Cirrhosis causes a decrease in methionine adenosyltransferase activity following a reduction in S-adenosylmethionine production and lower effectivity of the transsulfuration pathway [24]

Good dietary sources of lysine are high-protein foods such as eggs, meat, beans, peas, cheese and certain fish such as sardines and mackerel

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