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For this purpose, 4-chloro-3-hydroxybutyronitrile is synthesized from epichlorohydrin in an aqueous hydrogen cyanide solution, 4-chloro-3-hydroxy butyric acid alkyl ester is then synthesized from the 4-chloro-3-hydroxybutyronitrile in the presence of an alcohol and a sulfuric acid catalyst, and the racemic 4-chloro-3 -hydroxy butyric acid alkyl ester is hydrolyzed in an aqueous solution using an enzyme, thereby preparing (R)-4-chloro-3-hydroxy butyric acid alkyl ester

14) and requires fewer critical conserved nodes in the top half of the TM bundle (Supplementary Fig

Dysregulated iron metabolism triggers ferroptosis Lipid peroxidation and toxic ROS result from the iron-mediated Fenton reaction and enzymatic oxygenation, which are hallmark features of ferroptosis [32]

doi: 10.1021/acs.analchem.1c01743