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Sembolic is typically prescribed for adults with type 2 diabetes who need improved blood sugar control, or for adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related health condition such as hypertension, high cholesterol, or sleep apnea

The companys higher-dose version of Wegovy won FDA approval Thursday, based on trial results showing average weight loss of 21% over 72 weeks, putting it in the same league as Lillys Zepbound

The cyclization is formed via a lactam bridge between the side chains of Asp and Lys, constraining the peptide backbone into a stable, bioactive conformation