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American Diabetes Association Professional Practice C: 11

In a RDP clinical trial with 200 peri-menopausal women, a significant decrease of LDL cholesterol by 9.9% and a significant increase of HDL cholesterol by 4.6% were observed after six months of Pycnogenol (200 mg) supplementation ( supplementation by 3.9 and 3.5%, respectively, while after placebo systolic and diastolic blood pressures were decreased by 1.7 and 1%, respectively

Heart rate rose modestly in a dose-dependent way, peaking around week 24 before declining consistent with the broader GLP-1 class

A 2023 analysis found that patients on dual therapy achieved average weight reductions of 812% body weight over 52 weeks, with HbA1c reductions exceeding 2% in many cases