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Alcohol consumption in rats also decreases the levels of THTR-1 and THTR-2 in renal epithelial cells, thus limiting thiamin re-uptake by the kidneys (133)

However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

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564 Studies indicate that hepatic PPAR expression contributes to steatosis by promoting triglyceride synthesis and impairing glucose tolerance through monoacylglycerol O-acyltransferase 1 (MGAT1)