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In the foundational Novo Nordisk pharmacology studies, ipamorelin failed to elevate ACTH or cortisol at doses more than 200-fold above its ED50 for GH release a specificity profile that had not previously been achieved with any GHRP receptor agonist and that fundamentally changed the landscape of GH secretagogue research

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For instance, BMSC-Exos enriched with irisin-a peptide derived from FNDC5-overexpressing cells-enhanced neuronal viability, suppressed ferroptosis, and improved functional recovery in ischemic stroke models [137]