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For the treatment-regimen estimand, the mean body weight reductions from baseline at 72 weeks were 15.0%, 19.5%, and 20.9% in the tirzepatide 5, 10, and 15 mg groups, respectively, versus 3.1% in the placebo group

5.3 Underutilization of diet-based microbiota modulation Despite substantial evidence linking diet to microbiota composition and function, dietary interventions remain underemphasized in hypothyroidism management

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