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Participants were randomly assigned to one of five therapies: exenatide alone, dapagliflozin alone, dual therapy of exenatide and dapagliflozin, combined dapagliflozin and metformin therapy, or the weight-loss medication phentermine/topiramate extended-release

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Gallbladder disease In patients with established gallbladder disease, the relative risks and benefits of a cholecystectomy or preventive treatment with ursodeoxycholic acid before starting GLP-1 receptor agonist therapy should be thoroughly discussed