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There is also another medication, tirzepatide (brand names: Monjaro and Zepbound), which is a combination of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) agonists

Among the exendin 939 fragments, exendin 2029 specifically binds to TRPV1, alleviating pain in both acute and chronic pain models without interfering with GLP-1R function

Molecules like glucose, fructose, and galactose stimulate the synthesis of GLP-1 by closing ATP-sensitive K+ channels

Furthermore, precision medicine shows promise in this field, but more study is needed to discover reliable biomarkers or clinical traits that can predict individual reactions and aid in patient selection