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Many compounds that looked effective in animals later failed human trials or revealed safety concerns

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Hypoxia preconditioning attenuates bladder overdistension-induced oxidative injury by up-regulation of Bcl-2 in the rat

In recent years, specific GST isoforms have been implicated in the clearance of drugs and environmental toxicants, such as carcinogens and pesticides, as well as in the metabolism of endogenously produced compounds such as lipid peroxidation by-products 4, 5, 6, 7, 8, 9, 10