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These include: Smoking Excessive intake of sugar and refined carbohydrates Exposure to ultraviolet rays Signs of Collagen Deficiency The signs of collagen deficiency are visible to the naked eye

During anovulatory cycles or luteal regression after ovulation, the decreasing LH is related to a decreased LHCGR expression (45)

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GENE ONTOLOGY (GO): HIERARCHICAL FUNCTIONAL ANNOTATION Functional interpretation in omics often relies on structured vocabularies, and Gene Ontology (GO) provides a comprehensive hierarchical framework for classifying gene products by their functions (Gene Ontology Consortium, 2021)