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This project was also supported by National Institutes of Health/National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH, through UCSF-CTSI Grant UL1 RR024131 and TL-1 TR001871

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In addition to regaining weight, people returned to pre-drug levels of key markers of cardiometabolic health including blood pressure and cholesterol about 17 months after coming off all weight-loss drugs

Although these formulations did not specifically aim for mucus penetration or protection, they illustrate the potential of physical modulation strategies in overcoming anatomical and physiological barriers for systemic delivery