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In our translational work, we also reported a link between LAC levels, cellular aging and metabolic function in the antidepressant responses to the insulin-sensitizing agent pioglitazone, an agent for treatment of diabetes type 2 and tested as potential antidepressant [60]

Vaccine-induced respiratory mucosal immunity is vital for protection against SARS-CoV-1 in animal models [46], and greater numbers of total tissue-resident T cells in the lungs have been associated with protection from severe COVID-19 [47, 48]

From a structural perspective, our data indicate that binding of a SUMO moiety or of a non-SUMO substrate to the S1 site and binding of (acetyl-)CoA are mutually exclusive

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