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Trial SURMOUNT-OSA (NEJM 2024) Population 469 adults with moderate-to-severe OSA + obesity

Miguens-Gomez 2021): A fast, neural-based release within 10-15 minutes of eating A slower, nutrient-based release ~60 minutes after eating, especially when nutrients reach the lower GI tract, Eating too quickly may short-circuit the gut-brain connection

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Instead, it provides bacterial strains that generate metabolites (P9 protein, butyrate) which stimulate the body own L cells to produce and release natural GLP-1