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Glutamine mitigates oxidative stress-induced matrix degradation, ferroptosis, and pyroptosis in nucleus pulposus cells via deubiquitinating and stabilizing Nrf2

Reagent 1

Genetic polymorphisms in NMDAR subunits, such as NR1 and NR2B, influence individual sensitivity to the therapeutic and toxic effects of ketamine ( Comorbid conditions, such as diabetes and chronic kidney disease, amplify ketamines neurotoxicity by increasing oxidative stress and impairing drug metabolism

found that Erchen Decoction can also reduce levels of inflammatory factors (such as TNF- and IL-1) and enhance the mucosal barrier (e.g., by increasing ZO-1 levels)