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Here are some ways in which B12 contributes to skin health: Cell regeneration: Vitamin B12 is involved in DNA synthesis, which is essential for the production and regeneration of new cells, including skin cells

Reversible aggregation is a state in which the proteins and or peptides have aggregated, but over time dissociation and reversion back to the native and monomeric forms occur 25,26,27

[53] Causes of elevated IGF1 levels [edit] Medical conditions: acromegaly (especially when GH is also high) [45] delayed puberty [54] pregnancy [55] hyperthyroidism [55] some rare tumors, such as carcinoids, secreting IGF1 [56] Diet: High-protein diet [57] consumption of dairy products (except for cheese) [58] consumption of fish [58] IGF1 assay problems [55] Calorie restriction has been found to have no effect on IGF1 levels

This is my only theory