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Additionally, local NPY/AgRP neurons can secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which suppresses the activity of related POMC neurons, further enhancing appetite [40]

Progress in Cardiovascular Diseases, 77, 5969

Possible side effects of orlistat (Xenical/Alli) While the active ingredient orlistat which works by inhibiting the enzymes that break down fat in the gut, preventing your body from absorbing it debuted back in 1999 to a lot of fanfare, Fishman says its become less popular for two big reasons: side effects and minimal benefits. Those side effects are mostly gastrointestinal, and can include abdominal pain in up to 30% of patients