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Some retention is expected, but dramatic puffiness or rapid weight gain from fluid warrants dose reduction

If you have a leaner BMI and dont have a lot of metabolic issues, losing weight might take a little bit more time, about 3-6 months

it leads to use of higher insulin doses and is a cause of glycaemic variability, leading to both hyper- and hypoglycaemia [95, 96]

For example, dual-agent nanoplatforms co-delivering BH3 mimetics with low-dose doxorubicin have been proposed to exploit mitochondrial priming and DNA damage simultaneously, enhancing apoptosis while reducing the dose-dependent cardiotoxicity of doxorubicin