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The concentration of MOTS-c influenced the expressions of these genes, and knockdown of TGF- or SMAD7 partially reversed the increase in collagen expression, indicating the involvement of the TGF-/SMAD pathway

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By simultaneously activating the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors, it effectively promotes insulin secretion and reduces glucagon release, leading to better blood sugar regulation and weight loss support