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doi: 10.3389/fimmu.2017.01239 Received 27 June 2017 Accepted 19 September 2017 Published 29 September 2017 Volume 8 - 2017 Edited by Anna Rubartelli, IRCCS AOU San Martino IST, Italy Reviewed by Cecilia Garlanda, Istituto Clinico Humanitas, Italy

This article covers the biological mechanisms underlying the synergy, the specific dosing and timing protocols used in muscle research, the receptor dynamics that limit stacking duration, and the critical errors that cause most stacking protocols to underperform or fail entirely