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While the existing literature often addresses general dietary recommendations, few reviews integrate molecular mechanisms, population-level data, and interventional evidence linking nutrition with thyroid autoimmunity and cardiovascular risk

Higgins JPT, Altman DG, Sterne JAC: Chapter 8: Assessing risk of bias in included studies Version 5.1.0 (updated March 2011)

Most research suggests that it has a very high safety profile

Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism