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This calcium-dependent mechanism triggers rapid GH vesicle fusion and exocytosis independently of cAMP elevation, producing a fast, acute GH pulse that complements the transcriptionally-driven, cAMP-mediated GH synthesis supported by CJC-1295

However, a blanket recommendation has not been made in clinical guidelines as there are needs for stronger evidence and determinations of effective doses and specific patient populations that might benefit (Varadharaj et al., 2017)

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