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Patients should also be encouraged to report musculoskeletal symptoms early rather than assuming they are unrelated

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Additional modifications were produced to improve the original discovery, of which four emerged as most logical candidates for drug development, including GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH 2 ), Hexarelin (His-D-Mrp-Ala-Trp-D-Phe- Lys-NH 2 ), GHRP-2 (D-Ala-D--Nal-Ala-Trp-D-Phe-Lys) or pralmorelin which was most potent, and ipamorelin (Aib-His- D-2-Nal-D-Phe-Lys-NH 2 ) which persisted in the circulation longer than the other GHRPs 3