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Discussions around the compound also touch on possible anti-inflammatory effects and areas like neuroprotection or antimicrobial activity, although these topics remain part of ongoing research

More recently, a small-molecule APJ agonist partnered with BioAge failed in clinical development due to hepatotoxicity unrelated to target engagement, highlighting that off-target toxicity can arise independently of the signaling bias hypothesis (Ryffel et al., 2023)