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methyl-B12 500 g three times per week versus 1500 g once a week for 2 weeks, in 24 patients with PN and 10 healthy volunteers
Molecular formula: C10H11N2+
(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)
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