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At present, several studies have shown that patients with neurodegenerative diseases have some common pathological characteristics in the early stage of the disease: pathological protein aggregation and mitochondrial damage or mitochondrial dysfunction in vulnerable brain regions (Klemmensen et al., 2024

Inactivation of the proteasome system in fibroblast cells is related to the generation of singlet oxygen, protein oxidation and transcriptional agents that regulate MMP-1 expression activation (31)