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In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration

[31] The takeaway is vigilance: any GLP-1 user with diabetes especially on combined therapy with SGLT2 inhibitors, who presents with persistent vomiting or reduced oral intake deserves consideration for EDKA

Subcutaneous or intramuscular administration of BPC-157 and TB-500 may augment their therapeutic effects

Hendrie HC, SmithGamble V, Lane KA, Purnell C, Clark DO, Gao S