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The proportion of patients who experienced severe or confirmed ( 8 % at screening Semaglutide versus placebo as an add-on to SGLT2 inhibitor therapy (as monotherapy or in combination with a sulfonylurea derivative or metformin) Therapy with semaglutide at a dose of 1 mg once a week as an add-on to SGLT2 inhibitor therapy (as monotherapy or in combination with a sulfonylurea derivative or metformin) versus placebo once a week for 30 weeks resulted in statistically significant reductions in HbA1c (-1.5 % vs -0.1 %, respectively), FPG (-2.2 mmol/L vs
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Therefore, it is speculated to be a multi-factorial disorder, involving epigenetics, genetics and environmental factors
This medication was approved by the FDA in November 2023 for chronic weight management in adults who are obese or overweight with at least one weight-related condition, such as hypertension, type 2 diabetes, or high cholesterol
