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doi: 10.1016/j.bbr.2019.111902, PMID: [DOI] [PubMed] [Google Scholar] 144

Conversely, NRF2 induces the transcription of downstream genes such as HMOX1 and NQO1, neutralizing ROS and thereby alleviating necroptosis-mediated tissue injury [135]

This is why staying physically active is so important it helps counterbalance these metabolic changes