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Some individuals may experience weight loss as a result of improved blood sugar control and reduced insulin resistance

GLP-1-activated PKA inhibits voltage-gated potassium channels, prevents membrane repolarization, and prolongs VDC channel opening to promote Ca 2+ inward currents, contributing to GLP-1 stimulate insulin secretion, and the antagonistic effect of GLP-1R activation on Kv currents in cells requires transactivation of epidermal growth factor receptors, accompanied by signal conduction of cAMP/PKA and phosphatidylinositol-3-kinase (PI3K)/PKC signaling (MacDonald et al., 2003)

Additionally, some individuals may experience side effects, such as nausea or digestive issues, which often require adjusting the dosage under medical supervision

However, the adverse reactions caused by these drugs often limit their application