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AMPK and other signalling pathways, such as the insulin/IGF-1 signalling (IIS), rapamycin-targeting protein (mTOR), nuclear factor-B (NF-B), and deacetylase (Sirtuins) pathways, interact with each other to form a complex network closely related to longevity and ageing [76, 100]

Carolina E, et al

[DOI] [PubMed] [Google Scholar] 69.Chiang Y.F., Chen H.Y., Ali M., Shieh T.M., Huang Y.J., Wang K.L., Chang H.Y., Huang T.C., Hong Y.H., Hsia S.M

Researchers utilize this mechanism to explore downstream effects on SIRT1 activation, which is a critical regulator of mitochondrial biogenesis, fat oxidation, and glucose metabolism