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That size cutoff is the entire pharmacological bet, because small peptides are the part of a neurotrophic signal that might actually cross the blood-brain barrier, the gatekeeping wall that blocks the bodys own large growth factors from reaching the brain from the bloodstream

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Liu H, Sridhar VS, Perkins BA, Rosenstock J, Cherney DZI (2022) SGLT2 inhibition in type 1 diabetes with diabetic kidney disease: potential cardiorenal benefits can outweigh preventable risk of diabetic ketoacidosis

Heres what we do know from the few human reports available, and why they offer limited reassurance: Phase I trial (unpublished): In 2015, a formal Phase I trial on 42 healthy volunteers was initiated to assess BPC-157s safety and pharmacokinetics