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This is because tirzepatide works a bit differently from other similar medicines

Immune-Related Thyroiditis With Immune Checkpoint Inhibitors

GLP-1 drugs also slow gastric emptyingthe movement of food through the gastrointestinal tractwhich stops the gallbladder from dispensing bile

To mitigate these concerns, we included several proxy indicators in our propensity score matching, such as socioeconomic determinants (captured through ICD codes related to employment status, housing circumstances, and social environment), lifestyle counseling codes, and medication profiles that often correlate with health behaviors