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Erythrocytes dont have the intrinsic apoptotic machinery upstream of caspase-3, including cytochrome c or apoptotic peptidase-activating factor 1 (APAF-1) [22, 23]

3 , 4 , 5 , 6 , 7 , 8 An immunohistochemical study in a RP pig model suggested that the death of rods results in decreased oxygen consumption and hyperoxia in the outer retina resulting in gradual cone cell death from oxidative damage