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conducted a randomized controlled trial in obese older adults with cardiovascular or metabolic conditions, comparing three intervention groups: caloric restriction alone (WL), caloric restriction combined with aerobic training (WL + AT), and caloric restriction combined with resistance training (WL + RT)

Moreover, exposing mice to a low dose which reflects a typical American diet (0.01 mg/kg/day), caused gut microbiota alterations across two generations-consistent with earlier findings, Akkermansia muciniphila was depleted, while ParaBacteroides distasonis and Christensenellaceae were elevated in the second generation ( ParaBacteroides responses appear to vary between studies, as Buchenauer et al