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Selenoproteins play indelible roles in the process of life and diseases, and most selenoproteins are central sites for regulating redox homeostasis, such as GPX, SEPP1 and ER resident-selenoprotein SELS ( Piglets are susceptible to oxidative stress during birth and weaning, and oxidative stress can induce ER stress ( In order to further explore the specific mechanism of HMSeBA regulating intestinal ER stress signal, we established an ERS model of IPEC-J2 cells in vitro

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231 Methylation at arginine residue of KIX domain of CBP by coactivator-associated arginine methyltransferase 1 (CARM1) inhibits the interaction of CBP with CREB, thereby, blocking their downstream activity