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Mounjaro is approved to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes when used with diet and exercise

The risk appears dose-dependent and correlates with rapid weight loss velocity

Hunger returns because the appetite-suppressing effect is absent The satiety hormone GLP-1 is released back at its original level Due to previously reduced body weight, the basal metabolic rate may have decreased If dietary and exercise habits have not been permanently adjusted, the weight increases again Brajan Budini and Steven Luo from the University of Cambridge evaluated six randomized controlled trials with a total of over 3,200 patients

As compared to the prior regimen, initiation of oral semaglutide was associated with a significant reduction in the concomitant use of DPP-4 inhibitors (dropping to zero as expected), sulphonylureas, SGLT-2 inhibitors, and insulin (Fig