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Materials and Methods Study Design This was a retrospective, observational, longitudinal cohort study of US or UK adults with T2D who initiated a GLP-1 RA or BI between January 1, 2010 and June 30, 2016 and were followed up for 2 years up to June 30, 2018 (Figure S1)

Data were analyzed using custom made scripts in Matlab

46 Thyroid hormone receptor agonist: resmetirom (MGL-3196) Thyroid hormone receptor agonist, highly expressed in hepatocytes, regulates many metabolic pathways, including the reduction of triglyceride and cholesterol levels, improvement of insulin sensitivity, promotion of liver regeneration, and reduction of cell apoptosis

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