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Drug Monograph: rxlist.com (Nicotrol ) Keywords Cocaine Street Names: Coke, Flake, Snow, Blow, Toot, Base, Nose Candy, C, Line & numerous others Drug Class: DEA Schedule II: Topical Local anesthetic (Goprelto ) CNS stimulant & Drug of Abuse Mechanism of Action: Low concentrations block monoamine reuptake transport into nerve terminals (All three types: NET, DAT & SERT) (Kd 0.3 uM for NET) (Figure 1)

The more relevant research question is whether triple receptor agonism (GIP + GLP-1 + glucagon) combining elements of both approaches could outperform either dual agonist

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Collectively, these findings highlight the critical role of SLC25A39-mediated mitochondrial glutathione import in preventing a localized, intra-mitochondrial oxidative crisis that directly initiates apoptotic cell death