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Science 312, 13551359

Nitric oxide reacts with superoxide to form ONOO - , which can nitrate tyrosine residues and thus damage enzymes, and structural and functional proteins [1315, 25]

GLP-1 drugs are obesity and diabetes medicines that help regulate appetite and blood sugar, but they often require consistent, long-term use to maintain results

This review integrates molecular evolution, formulation advances, and biopharmaceutics modeling, including physiologically based biopharmaceutics modeling (PBBM), to illustrate emerging strategies shaping next-generation oral peptide therapeutics